Reagents and conditions: (i) propynoic acid, DCC, DMAP, CH2Cl2, room temp, 24 h; (ii) 1,3-dibromopropane, anhydrous K2CO3, acetone, reflux, 12 h; (iii) 2-(piperazin-1-yl)ethanol, pyridine, toluene, reflux, 4 h; (iv) 1, anhydrous THF, 30 min; (v) 2, anhydrous K2CO3, acetone, reflux, 12 h.